pco.edge 4.2 USB sCMOS Camera
The pco.edge 4.2 USB scientific camera is equipped with an innovative scientific CMOS (sCMOS) sensor that allows exceptional image quality and precise measurements. With the ability to capture crisp images, the pco.edge 4.2 USB sCMOS camera system is ideal for applications requiring highest quantum efficiency, best 16-bit dynamic range, high frame rates, long exposure times, and extremely low readout noise.
With a very high quantum efficiency (QE), the pco.edge 4.2 USB camera is the ideal choice when high sensitivity is required. The easy-to-connect USB 3.0 interface allows this camera to be used on any device, even notebooks. The sensor is stabilized to 0 °C to reduce the influence of noise and guarantee highest image quality.
| Length | 99.5 mm |
| Width | 70.0 mm |
| Height | 76.0 mm |
| Weight (kg) | 0.75 |
| Dynamic Range (log) | 91.0 dB |
| Forced Air | true |
| Readout Noise RMS | 1.5 e- |
| Pixel Size (H x V) | 6.5 x 6.5 |
| Thermo Electric Cooling | true |
| Frame rate (Full Sensor) | 40.0 fps |
| Peak Quantum Efficiency | 80.0 % |
| Dark Current | 0.3 e-/s |
| Working Temperature Image Sensor | 0 °C stabilized (up to +27 °C ambient temperature) |
| Peak Quantum Efficiency Wavelength | 580.0 nm |
| Readout Noise Median | 0.8 e- |
| Sensor Technology | sCMOS FSI |
| Sensor Version | CIS2020 |
| Fullwell Capacity | 30000 e- |
| Sensor Temperature (Dark Current Reference) | 0.0 °C |
| Operational Modes |
Rolling Shutter with Selectable Readout Direction Global Reset |
| Dynamic Range A/D Converter | 16 bit |
| Dynamic Range | 37500:1 |
| Resolution (H x V) | 2048 x 2048 |
| Sensor Diagonal | 18.8 mm |
| Liquid Cooling | true |
| Included Lens Mount |
C-Mount F-Mount |
| Data Interface | USB 3.0 |
| Line Scanning | false |
| Global Reset | true |
| Trigger Input Signals |
external exposure start external exposure control sequence trigger acquire enable |
| Global Shutter | false |
| Region of Interest Vertical (ROI) | vertical: steps of 1 row (min. 16) |
| Non Linearity | ≤ 0.6 % |
| MTF (Theoretical) | 76.9 lp/mm |
| Optional Lens Mount | TFL-Mount |
| Spectral Range Minimum | 300 nm |
| Dark Signal Non-Uniformity DSNU | 0.3 e- (rms) |
| Binning Vertical |
x2 x4 |
| Bining Method | sum |
| Binning Horizontal |
x2 x4 |
| Default Read Out Mode | Rolling Shutter with Selectable Readout Direction |
| Operating Temperature Range | +10 °C to +40 °C |
| Photo Response Non-Uniformity PRNU | ≤ 0.2 % |
| Sensor Manufacturer | Fairchild Imaging |
| Power Supply | 24 VDC (±10 %) |
| Exposure Minimum |
100 μs 30 μs |
| Sensor Dimensions (H x V) | 13.3 x 13.3 |
| Spectral Range Maximum | 1100 nm |
| A/D Conversion Factor | 0.46 e-/DN |
| Direct Mounting Distance (No Camera Flange) | 11.1 mm (±10 %) |
| Chroma | mono |
| Rolling Shutter | true |
| Humidity Range (Non-Condensing) | 10 % to 80 % (recommended < 65 %) |
| Trigger Cable Connector | SMA |
| Double Shutter | false |
| Read Out Mode: Set Parameter | Shutter Mode |
| Power Consumption | max. 21 W |
| Storage Temperature Range | -10 °C to +60 °C |
| Pixel Rate | 220 MPixel/s |
| Exposure Maximum |
20 s 2 s |
| Compliance Label |
CE FCC UKCA KC |
| Region of Interest Horizontal (ROI) | horizontal: steps of 4 columns (min. 64) |
| Trigger Output Signals |
exposure busy line |
| Part Number | 85108072513 |
- Bright-field microscopy
- Fluorescence microscopy
- Digital pathology
- Single molecule localization microscopy (SMLM) – PALM, STORM, dSTORM, GSDIM
- Lightsheet fluorescence microscopy (LSFM)
- Structured illumination microscopy (SIM)
- Calcium imaging
- Förster resonance energy transfer (FRET)
- Fluorescence recovery after photobleaching (FRAP)
- High-speed bright-field ratio imaging
- High throughput screening | high content screening
- Biochip reading
- Total internal reflection microscopy (TITF)
- Spinning disk confocal microscopy
- 3D metrology
- Ophthalmology
- Photovoltaic inspection
- Industrial quality inspection
- Wafer inspection
- Image intensifier imaging
- Lucky astronomy
- Particle tracking velocimetry (PTV)


| Length | 99.5 mm |
| Width | 70.0 mm |
| Height | 76.0 mm |
| Weight (kg) | 0.75 |
| Dynamic Range (log) | 91.0 dB |
| Forced Air | true |
| Readout Noise RMS | 1.5 e- |
| Pixel Size (H x V) | 6.5 x 6.5 |
| Thermo Electric Cooling | true |
| Frame rate (Full Sensor) | 40.0 fps |
| Peak Quantum Efficiency | 80.0 % |
| Dark Current | 0.3 e-/s |
| Working Temperature Image Sensor | 0 °C stabilized (up to +27 °C ambient temperature) |
| Peak Quantum Efficiency Wavelength | 580.0 nm |
| Readout Noise Median | 0.8 e- |
| Sensor Technology | sCMOS FSI |
| Sensor Version | CIS2020 |
| Fullwell Capacity | 30000 e- |
| Sensor Temperature (Dark Current Reference) | 0.0 °C |
| Operational Modes |
Rolling Shutter with Selectable Readout Direction Global Reset |
| Dynamic Range A/D Converter | 16 bit |
| Dynamic Range | 37500:1 |
| Resolution (H x V) | 2048 x 2048 |
| Sensor Diagonal | 18.8 mm |
| Liquid Cooling | true |
| Included Lens Mount |
C-Mount F-Mount |
| Data Interface | USB 3.0 |
| Line Scanning | false |
| Global Reset | true |
| Trigger Input Signals |
external exposure start external exposure control sequence trigger acquire enable |
| Global Shutter | false |
| Region of Interest Vertical (ROI) | vertical: steps of 1 row (min. 16) |
| Non Linearity | ≤ 0.6 % |
| MTF (Theoretical) | 76.9 lp/mm |
| Optional Lens Mount | TFL-Mount |
| Spectral Range Minimum | 300 nm |
| Dark Signal Non-Uniformity DSNU | 0.3 e- (rms) |
| Binning Vertical |
x2 x4 |
| Bining Method | sum |
| Binning Horizontal |
x2 x4 |
| Default Read Out Mode | Rolling Shutter with Selectable Readout Direction |
| Operating Temperature Range | +10 °C to +40 °C |
| Photo Response Non-Uniformity PRNU | ≤ 0.2 % |
| Sensor Manufacturer | Fairchild Imaging |
| Power Supply | 24 VDC (±10 %) |
| Exposure Minimum |
100 μs 30 μs |
| Sensor Dimensions (H x V) | 13.3 x 13.3 |
| Spectral Range Maximum | 1100 nm |
| A/D Conversion Factor | 0.46 e-/DN |
| Direct Mounting Distance (No Camera Flange) | 11.1 mm (±10 %) |
| Chroma | mono |
| Rolling Shutter | true |
| Humidity Range (Non-Condensing) | 10 % to 80 % (recommended < 65 %) |
| Trigger Cable Connector | SMA |
| Double Shutter | false |
| Read Out Mode: Set Parameter | Shutter Mode |
| Power Consumption | max. 21 W |
| Storage Temperature Range | -10 °C to +60 °C |
| Pixel Rate | 220 MPixel/s |
| Exposure Maximum |
20 s 2 s |
| Compliance Label |
CE FCC UKCA KC |
| Region of Interest Horizontal (ROI) | horizontal: steps of 4 columns (min. 64) |
| Trigger Output Signals |
exposure busy line |
| Part Number | 85108072513 |
- Bright-field microscopy
- Fluorescence microscopy
- Digital pathology
- Single molecule localization microscopy (SMLM) – PALM, STORM, dSTORM, GSDIM
- Lightsheet fluorescence microscopy (LSFM)
- Structured illumination microscopy (SIM)
- Calcium imaging
- Förster resonance energy transfer (FRET)
- Fluorescence recovery after photobleaching (FRAP)
- High-speed bright-field ratio imaging
- High throughput screening | high content screening
- Biochip reading
- Total internal reflection microscopy (TITF)
- Spinning disk confocal microscopy
- 3D metrology
- Ophthalmology
- Photovoltaic inspection
- Industrial quality inspection
- Wafer inspection
- Image intensifier imaging
- Lucky astronomy
- Particle tracking velocimetry (PTV)


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